A case of pulmonary tumour thrombotic microangiopathy

A case of pulmonary tumour thrombotic microangiopathy.

Pulmonary tumour thrombotic microangiopathy (PTTM) is a rapidly progressive pulmonary disease that is a fatal complication of malignancy. It manifests clinically as subacute respiratory failure with pulmonary hypertension, progressive right sided heart failure, and sudden death. We describe here a case of PTTM associated with occult metastatic signet ring cell carcinoma of the stomach. Although...

Pulmonary tumour thrombotic microangiopathy: unclassifiable pulmonary hypertension?

References 1 Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2013; 62: D34–D41. 2 Gurtner HP. Aminorex and pulmonary hypertension. A review. Cor Vasa 1985; 27: 160–171. 3 Kay JM, Smith P, Heath D. Aminorex and the pulmonary circulation. Thorax 1971; 26: 262–270. 4 Simonneau G, Fartoukh M, Sitbon O, et al. Primary pulmonary...

Pulmonary tumour thrombotic microangiopathy: unclassifiable pulmonary hypertension?

Pulmonary hypertension (PH) is defined as a mean pulmonary artery pressure ⩾25 mmHg, and can be associated with multiple conditions. The diagnostic strategy and treatment of PH is heavily reliant on accurately classifying patients [1]. We recently identified two patients presenting with rapidly fatal PH of unknown aetiology, who were subsequently diagnosed at post mortem with pulmonary tumour t...

Pulmonary Tumor Thrombotic Microangiopathy

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare clinical entity where tumor cell embolisms in pulmonary circulation induce thrombotic microangiopathy (TMA), respiratory failure, and subacute cor pulmonale. We describe 3 cases of PTTM that presented as the initial manifestation of metastatic gastric adenocarcinoma with TMA and pulmonary infiltrates. All 3 cases had similar clinical a...

Pulmonary tumour thrombotic microangiopathy due to adenocarcinoma of the lung. A cause of pulmonary hypertension.